In 2000-2001, the federal government phased out the household use of chlorpyrifos and diazinon. In the current study, Dr. Robin M. Whyatt, from Columbia University in New York, and colleagues assessed the effect of this ban on the outcomes of 314 infants born in New York City. The infants were divided into groups based on whether their birth occurred before or after January 1, 2001.
The findings are reported in Environmental Health Perspectives.
Consistent with their own previous report, the authors found that both birth weight and length decreased as umbilical cord levels of chlorpyrifos rose. A similar relationship was observed for diazinon. In contrast, propoxur, another insecticide, was only weakly linked with decreased birth length.
The average weight difference between babies with the highest and lowest levels of pesticide exposure was 186.3 grams, the investigators report.
Infants born after January 1, 2001 had substantially lower pesticide exposure levels than those born before this date, the researchers report. Moreover, the levels present in the less-exposed group seemed to have no effect on growth.
"This human study confirms the developmental impact, shown previously in animal studies, of these insecticides," Whyatt said in a statement. "It also demonstrates the positive effect of the federal ban, which has substantially reduced exposures and benefited human health."
"The differences in fetal growth seen here are comparable to the differences between babies whose mothers smoke during pregnancy," Whyatt noted. "The fact that the ban was associated with such an immediate change in birth weight and length provides considerable evidence of cause and effect."