The miners have been out of contact since the flood in the Tengda mine in Jiaohe city in the early morning Chinese time, the agency quoted local sources saying. Urgent rescue operations were underway and the cause of the accident is being investigated.
China's mining industry is plagued by explosions, floods and other underground disasters, which killed 1,113 people in the first three months of the year.
The government has pledged some 3 billion yuan ($362.5 million) to improve safety standards but has found it hard to curb the problem in the face of strong demand for coal, which accounts for around two-thirds of the country's energy consumption.